The original Port Pirie railway station was built by the docks in 1875. For many years the running of trains in the main street was troublesome. The station closed in July 1967. The building became a museum. Even though a small museum there are plenty of exhibits showing the towns history. The locomotive is in a closed off yard, but there is a good view from the road. The railway to the smelter runs behind the museum.

The new Port Pirie station used to have the Indian - Pacific trains stop there. When the train arrived, the cooking coach would be exchanged. A new restocked coach joined the train complete with a cooked meal ready to serve to the passengers. Now the train bypasses Port Pirie and stops at Adelaide instead. The long platform at Port Pirie no longer sees any passenger trains only freight to the smelter and grain trains to the huge silos at the docks.